Martina Nicoletti, Anna Crispino, Alessandro Loppini, Alessio Gizzi, Letizia Chiodo, Christian Cherubini, and Simonetta Filippi
Spatially discordant alternans (SDA) play a crucial role in cardiac arrhythmogenesis by creating steep repolarization gradients facilitating conduction block and reentry. While traditionally studied using electrical indicators, this work provides a novel perspective by characterizing SDA through their magnetic field signatures. Using a one-dimensional cardiac fiber model, we demonstrate that magnetic field measurements effectively detect SDA and temperature dependent changes in cardiac action potentials, offering a non-invasive alternative to conventional electrophysiological metrics. Our results reveal that the spatial organization of SDA is mirrored in the magnetic field distribution, with SDA nodes clearly identifiable via spatial mapping. Notably, magnetic restitution curves exhibit a distinct pattern from APD-based indicators, closely following the dynamics of the action potential upstroke. These findings establish the cardiac magnetic field as a powerful diagnostic tool for detecting SDA, opening new avenues for biomagnetic monitoring of arrhythmic risk.